Following statements are regarding to apoptosis. A. In the worm apoptotic pathway, CED-3 (caspase-9 in mammals) is a protease required to destroy cell components during apoptosis. B. CED-4 (Apaf-1) was able to accelerate the autoproteolytic cleavage and activation of purified CED-9 C. Once EGL-1 causes dissociation of the CED-4/CED-9 complex, the released CED-4 dimer joins with three other CED-4 dimers to make an octamer, which then activates CED-3 D. Many apoptotic stimuli lead to damage of the outer mitochondrial membrane, causing release into the cytosol of several proteins that stimulate apoptosis. In particular, cytochrome c released from mitochondria activates Apaf-1, which in turn activates caspase-3 and 7. Which of the following combination is incorrect? -triyambak.org