Conversion of a proto-oncogene into an oncogene, also called activation, generally involves a gain-of-function mutation. Following statements are regarding to the mechanisms that produce oncogenes from the corresponding proto-oncogenes.

A. A change in a single base pair in a proto-oncogene that results in a hyperactive or constitutively active protein product.

B. A chromosomal translocation that fuses two genes together to produce a hybrid gene encoding a chimeric protein whose activity, unlike that of the parent proteins, is permanently suppress.

C. A chromosomal translocation that brings a growth regulatory gene under the control of alternative enhancers that cause inappropriate expression of the gene.

D. Amplification of a DNA segment including a proto-oncogene so that numerous copies exist, leading to overproduction of the encoded protein.

Which of the following statements are correct?

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#Question id: 12949

#Unit 7. System Physiology – Animal

At which renal tubular sites would the concentration of creatinine be expected to be highest in a normally hydrated person?

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#Question id: 12701

#Unit 7. System Physiology – Animal

In chronic respiratory acidosis with partial renal compensation, you would expect to find the following changes, compared to normal:___ urinary excretion of NH4+; ______ plasma HCO3− concentration; and _____ urine pH.

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#Question id: 12700

#Unit 7. System Physiology – Animal

A young man is found comatose, having taking an unknown number of sleeping pills an unknown time before. An arterial blood sample yields the following values: pH = 7.02, HCO3− = 14 mEq/L, and PCO2 = 68 mm Hg. This patient’s acid–base status is most accurately described as

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#Question id: 12699

#Unit 7. System Physiology – Animal

The following test results were obtained: urine flow rate = 2.0 ml/min; urine inulin concentration = 60 mg/ml; plasma inulin concentration = 2 mg/ml; urine potassium concentration = 20 μmol/ml; plasma potassium concentration = 4.0 μmol/ml; urine osmolarity = 150 mOsm/L; and plasma osmolarity = 300 mOsm/L. What is the free water clearance rate?

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#Question id: 12698

#Unit 7. System Physiology – Animal

The following test results were obtained: urine flow rate = 2.0 ml/min; urine inulin concentration = 60 mg/ml; plasma inulin concentration = 2 mg/ml; urine potassium concentration = 20 μmol/ml; plasma potassium concentration = 4.0 μmol/ml; urine osmolarity = 150 mOsm/L; and plasma osmolarity = 300 mOsm/L. What is the net potassium reabsorption rate?

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#Question id: 12697

#Unit 7. System Physiology – Animal

The following test results were obtained: urine flow rate = 2.0 ml/min; urine inulin concentration = 60 mg/ml; plasma inulin concentration = 2 mg/ml; urine potassium concentration = 20 μmol/ml; plasma potassium concentration = 4.0 μmol/ml; urine osmolarity = 150 mOsm/L; and plasma osmolarity = 300 mOsm/L. What is the approximate GFR?