we examine how the deregulation of growth-promoting and growth-inhibiting signaling pathways contributes to tumorigenesis. Mutations-

A. A mutation that alters a single amino acid (valine to glutamine) in the transmembrane region of the HER2 receptor

B. A deletion that causes loss of the extracellular ligand-binding domain in the EGF receptor Results-

i. dimerization of the receptor, even in the absence of the normal EGF-related ligand, transforming it into the oncoprotein, a constitutively active kinase

ii. to constitutive activation of the kinase activity of the resulting oncoprotein

iii. no dimerization, even in the presence of the normal EGF-related ligand, repression of kinase activity

which of the following results are displayed after these mutations?

#Question id: 11630

#Unit 8. Inheritance Biology

What is the F2 phenotypic ratio in 3 QTL?

#Question id: 11629

#Unit 8. Inheritance Biology

Two pure line plants of 46 cm and 10 cm in height cross each other forming F1 progeny 28 cm in height,  what is the no. of QTL formed?

#Question id: 11628

#Unit 8. Inheritance Biology

Two  varieties of maize averaging of 180 cm and  20cm, inches in height respectively, are crossed. The F1 progeny is quite uniform averaging  100cm in height. How many different  Phenotype express in f2 generation?

#Question id: 5372

#Unit 8. Inheritance Biology

Consider the following diagrams, each being a different situation in which an entire gene is represented in a higher organism. In some cases, a point mutation exists (indicated by p). In other cases, a deletion has occurred (indicated by xxxxx), both of which render the gene nonfunctional

Which of the following homozygous cross would produce wild type phenotype?

#Question id: 5371

#Unit 8. Inheritance Biology

The trait represented in the following pedigree (shaded symbols) is known to be inherited as a single dominant gene. Calculate the probability of the trait appearing in the offspring if the first cousins should marry and have children.

#Question id: 5370

#Unit 8. Inheritance Biology

The pedigree below represents the inheritance of an X link recessive trait. The probability of effected child in fourth generation of family?