we examine how the deregulation of growth-promoting and growth-inhibiting signaling pathways contributes to tumorigenesis. Mutations-

A. A mutation that alters a single amino acid (valine to glutamine) in the transmembrane region of the HER2 receptor

B. A deletion that causes loss of the extracellular ligand-binding domain in the EGF receptor Results-

i. dimerization of the receptor, even in the absence of the normal EGF-related ligand, transforming it into the oncoprotein, a constitutively active kinase

ii. to constitutive activation of the kinase activity of the resulting oncoprotein

iii. no dimerization, even in the presence of the normal EGF-related ligand, repression of kinase activity

which of the following results are displayed after these mutations?

#Question id: 3398

#Unit 11. Evolution and Behavior

Genetic drift in a small population for multiple generations can significantly affect the composition of a population’s gene pool. Following some observation are given for reason of Genetic drift?

A) Small populations are threatened by a loss of genetic variability. This loss may be caused by inbreeding, genetic drift, and limited mating.

B) Sampling error can arise is through the founder effect, which is due to the limited matting within population

C) Genetic drift arises is through a genetic bottleneck, which develops when a population undergoes a drastic reduction in population size.

D) Variance in allele frequency due to genetic drift will be maximal when one allele is very rare and the population size is small.

Which of the above observation are true?

#Question id: 5200

#Unit 11. Evolution and Behavior

What is the difference between a linkage map and a physical map?

#Question id: 5201

#Unit 11. Evolution and Behavior

How is a physical map of the genome of an organism achieved?

#Question id: 5202

#Unit 11. Evolution and Behavior

Which of the following most correctly describes a shotgun technique for sequencing a genome?

#Question id: 5205

#Unit 11. Evolution and Behavior

Why is it preferable to use large computers and databases in searching for individual genes, rather than testing each sequence for possible function?

#Question id: 5207

#Unit 11. Evolution and Behavior

Why is it unwise to try to relate an organismʹs complexity with its size or number of cells?