we examine how the deregulation of growth-promoting and growth-inhibiting signaling pathways contributes to tumorigenesis. Mutations-

A. A mutation that alters a single amino acid (valine to glutamine) in the transmembrane region of the HER2 receptor

B. A deletion that causes loss of the extracellular ligand-binding domain in the EGF receptor Results-

i. dimerization of the receptor, even in the absence of the normal EGF-related ligand, transforming it into the oncoprotein, a constitutively active kinase

ii. to constitutive activation of the kinase activity of the resulting oncoprotein

iii. no dimerization, even in the presence of the normal EGF-related ligand, repression of kinase activity

which of the following results are displayed after these mutations?

TLS Online TPP Program

#Question id: 27422

#Unit 1. Molecules and their Interaction Relevant to Biology

There are two extreme states of bilayer lipids choose which of the following is correct  

1.In the liquid- ordered (Lo) state, polar head groups are non uniformly arrayed at the surface, and the acyl chains are nearly motionless and packed with irregular

2.in the liquid- ordered (Lo) state, polar head groups are uniformly arrayed at the surface, and the acyl chains are nearly motionless and packed with regular

3.In the liquid-disordered (Ld) state acyl chains undergo much thermal motion and have regular organization.

4.In the liquid-disordered (Ld) state, acyl chains undergo much thermal motion and have no regular organization.

TLS Online TPP Program

#Question id: 27421

#Unit 1. Molecules and their Interaction Relevant to Biology

Highest concentration of cholesterol are found in

TLS Online TPP Program

#Question id: 27420

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following membrane do not have cholesterol

1.Plasma membrane (E. coli)

2.Outer mitochondrial membrane (cauliflower)

3.Inner mitochondrial membrane (cauliflower)

4.Chloroplast inner membrane

TLS Online TPP Program

#Question id: 27416

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following statement is true

1. Wedge or cone shape lipid promote the formation of monolayer micelle 

2. Wedge or cone shape lipid promote the formation of lipid bilayer 

3. Cylindrical shaped lipid majorly promote the formation of perfect  lipid bilayer region

4. Cylindrical shaped lipid majorly promote the formation of monolayer micelle

TLS Online TPP Program

#Question id: 27415

#Unit 1. Molecules and their Interaction Relevant to Biology

Lipid aggregation are catalyzed by which of the following bond effect

TLS Online TPP Program

#Question id: 27414

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is correctly describing the common structure of any sterol