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TLS Online TPP Program

#Question id: 7264

The Dictyostelia social amoebas are found in a wide range of soil habitats. They can come together to form a fruiting structure, in which a proportion of cells are sacrificed to build the stalk and the remainder differentiate into resilient dormant spores. This multicellular life cycle is common to all Dictyostelids. It consists of an interconnected programme of cell movement and cell differentiation, and has been intensively studied in the model organism D. discoideum. Few mutants (Column A) and phenotypes (Column B) are listed in the table given below.

    Column A

    Column B

A. Loss of function of cAMP-dependent protein kinase (PKA)

i. cell develop normally but unable to germinate

B. Loss of function of RegA

ii. Loose aggregate form

C. Loss of function of adenylate cyclase B

iii. No aggregation

D. Loss of function of gp80

iv. accumulation of cAMP and PKA activation

 Match the correct mutant with the observed phenotype.

#Unit 5. Developmental Biology
  1. A-iv, B-ii, C-iii, D-i
  2. A-iv, B-iii, C-i, D-ii
  3. A-ii, B-iii, C-iv, D-i
  4. A-iii, B-iv, C-i, D-ii
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TLS Online TPP Program

#Question id: 24223

#Unit 1. Molecules and their Interaction Relevant to Biology

Phosphoglycerate mutase catalyses a reversible shift of the phosphoryl group between C-2 and C-3 of glycerate; which of the following ion is essential for this reaction
TLS Online TPP Program

#Question id: 24222

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following reaction of glycolysis is irreversible
1. Glucose is converted to glucose 6-phosphate in the presence of the enzyme hexokinase.
2. Fructose 6-phosphate is converted to fructose 1,6-biphosphate in the presence of the enzyme phosphofructokinase.
3. Phosphoenolpyruvate is converted to pyruvate in the presence of the enzyme pyruvate kinase.
4. isomerization of glucose 6-phosphate to fructose 6-phosphate
TLS Online TPP Program

#Question id: 24221

#Unit 1. Molecules and their Interaction Relevant to Biology

Glucagon lowers the cellular level of fructose 2,6 bisphosphate by
TLS Online TPP Program

#Question id: 24220

#Unit 1. Molecules and their Interaction Relevant to Biology

Glucagon stimulates cAMP from ATP. Cyclic AMP then activates cAMP-dependent protein kinase, phosphorylates PFK-2/FBPase-2. Phosphorylation of this protein enhances its FBPase-2 activity and inhibits its PFK-2 activity resulting
TLS Online TPP Program

#Question id: 24219

#Unit 1. Molecules and their Interaction Relevant to Biology

When Fructose 2,6-bisphosphate binds to its allosteric site on PFK-1 results
TLS Online TPP Program

#Question id: 24218

#Unit 1. Molecules and their Interaction Relevant to Biology

Phosphorylation of fructose 6-phosphate, catalysed by