The following statements are related to pentose phosphate pathway.

a) The first and third steps are oxidations with large, negative standard free-energy changes and are essentially irreversible in the cell

b) NADPH rises and inhibits the first enzyme in the pentose phosphate pathway. As a result, more glucose 6-phosphate is available for glycolysis

c) All the enzymes of the reversible reaction of the pentose phosphate pathway are located in the cytosol

d) The NADPH is used for biosynthetic reactions such as lipid synthesis and nitrogen assimilation in the cytosol

which one of the following combination  of above statements is incorrect?

#Question id: 1395

#Unit 4. Cell Communication and Cell Signaling

Which of the following mutations would promote malignancy in cells whose proliferation is inhibited by TGFβ?

a. overexpression of Smad2               

b. loss of Smad 4

c. overexpression of TGFβ receptor I

d. loss of TGFβ receptor II

#Question id: 1396

#Unit 4. Cell Communication and Cell Signaling

Trks are:

a. endonucleases.        b. transmembrane receptors.   c. proteases.     d. protein kinases.      

#Question id: 1397

#Unit 4. Cell Communication and Cell Signaling

The vertebrate equivalent of CED-9 is:

#Question id: 1398

#Unit 4. Cell Communication and Cell Signaling

Which of the following properties is (are) characteristic of a benign tumor?

a. well differentiated              b. localized to tissue of origin             c. metastatic               

d. promotes angiogenesis        e. surrounded by a fibrous capsule

#Question id: 1399

#Unit 4. Cell Communication and Cell Signaling

Loss-of-function mutations in which of the following genes typifies colorectal carcinomas?

a. myc              b. K-ras                       c. p53              d. APC

#Question id: 1400

#Unit 4. Cell Communication and Cell Signaling

Which property is shared by malignant tumor cells and transformed cells in culture?

a. reduced growth factor requirement                        b. attachment-dependent growth

c. loss of actin microfilaments                                    d. altered morphology