When two excitatory postsynaptic potentials (EPSPs) occur at a single synapse so rapidly in succession that the postsynaptic neuron's membrane potential has not returned to the resting potential before the second EPSP arrives, the EPSPs add together producing ________.

#Question id: 26940

#Unit 10. Ecological Principles

#Question id: 1424

#Unit 4. Cell Communication and Cell Signaling

Gain-of-function mutations in which of the following genes typify colorectal carcinomas?

#Question id: 10302

#Unit 7. System Physiology – Animal

During respiration, given below some of the reaction of glycolysis are irreversible which are bypass during gluconeogenesis,which of the following ics correcty involve in

#Question id: 1520

#Unit 4. Cell Communication and Cell Signaling

Following statements are regarding to enzymatic processing of benzo(a)pyrene to a more potent mutagen and carcinogen.

A. Liver enzymes, particularly P-450 enzymes, modify benzo(a)pyrene in a series of reactions, producing 7,8-diol-9,10-epoxide, a highly potent mutagenic species that reacts with DNA primarily at the N2 atom of a guanine base.

B. The adduct, (+)-trans-anti-B(a)P-N2-dG, causes polymerase to insert an A rather than a C opposite the modified G base. Next time the DNA is replicated, a T will be inserted opposite the A, and the mutation will be complete.

C. Potent mutagen majorly causes conversion of guanine (G) to thymine (T) bases, a transition mutation.

D. When this potent mutagen applied to cultured bronchial epithelial cells, activated benzo(a)pyrene induces many mutations, including activating mutations at codons 175, 248, and 273 of the p53 gene.

Which of the following statements are correct?

#Question id: 15528

#Unit 4. Cell Communication and Cell Signaling