Cystic fibrosis (CF) is an inherited disorder of the exocrine glands, affecting children and young people. Mucus in the exocrine glands becomes thick and sticky and eventually blocks the ducts of these glands (especially in the pancreas, lungs, and liver), forming cysts. A primary disruption in the transfer of which ion across cell membranes occurs in CF leading to decreased secretion of fluid?

TLS Online TPP Program

#Question id: 26444

#Unit 3. Fundamental Processes

global genome repair (GG-NER) depending on proteins

TLS Online TPP Program

#Question id: 26443

#Unit 3. Fundamental Processes

XP-V is caused by a defect in the translesion DNA polymerase

TLS Online TPP Program

#Question id: 26441

#Unit 3. Fundamental Processes

NER component and their functions are given, match them correctly

Component	Function
1. UvrA	a. DNA Pol I and DNA ligase
2. UvrB dimer	b. creates two incisions
3. UvrC	c. melts the DNA to create a single-stranded bubble around the lesion
4. DNA Pol I and DNA ligase	d. scanned Distortion

TLS Online TPP Program

#Question id: 26440

#Unit 3. Fundamental Processes

Choose the correct statement 

a. Long patch repair system is accomplished by Lig1, FEN1, Pol ζ ε, and APE1 

b. Long patch repair system is accomplished by Lig3, FEN1, Pol ξ β ,APE1 & lyase action

c. Short patch repair system is accomplished by Lig3, FEN1, Pol  ξ β,APE1 & lyase action

d. Short patch repair system is accomplished by Lig1, FEN1, Pol ζ ε, , and APE1

TLS Online TPP Program

#Question id: 26439

#Unit 3. Fundamental Processes

Which of the following Mut system involve in the rectification of oxygen damage

TLS Online TPP Program

#Question id: 26438

#Unit 3. Fundamental Processes

 Preferential removal of bases in pairs that have oxidized guanine is designed to minimize mutations using different Mut system having specific functions match them correctly

Mut system	Mutational pairing
1. MutT	a. removes G=O that is paired with C
2. MutM	b. removes A that is paired with G=O
3. MutY	c. hydrolyzes 8-oxo-dGTP