TLS Online TPP Program

#Question id: 15003


Laurie met her husband Jim at a support group for families dealing with PKU (phenylketonurea), a recessive genetic disorder. Laurie and Jim both have one sister who is affected with PKU and no other family history of the disorder. They come to you as a genetic counselor to ask what their risk is of having an affected child. What do you tell them?

#Unit 8. Inheritance Biology
  1. They must both be heterozygotes so their risk of having an affected child is ¼.
  2. They must both be heterozygotes so their should tested to see if they carry the disease allele or not
  3. Since neither one of them is affected, they are not at risk of having an affected child.
  4. You can't give them any firm answers because you don't know their genotypes.