The herbaceous plant Achillea lanulosa is widespread in the Northern Hemisphere. Phenotypic variation in the species has been extensively studied along an altitudinal gradient from sea level to over 3,000 meters. In California there is conspicuous variation in  height; alpine plants are only several centimeters tall  while  those in  the San Joaquin Valley may reach a height of 1.8 meters. Adaptation to different local environments also results in variation in physiological processes such as photosynthetic rate, resistance to cold, and the timing of dormancy.

Which of the following methods would be best to determine whether the phenotypic variation in Achillea lanulosa is due to genotypic variation?

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#Question id: 15364

#Unit 4. Cell Communication and Cell Signaling

In normal cells, FOS and MYC mRNAs and the proteins they encode are intrinsically unstable and degrade rapidly after the genes are transcribed, Conversion of the MYC proto-oncogene into an oncogene can occur by different mechanisms, Other members of this protein set include MAD, MAX, and MNT, choose incorrect statement regarding this,

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#Question id: 15363

#Unit 4. Cell Communication and Cell Signaling

Epithelial-to-mesenchymal transition (EMT) is thought to play a crucial role during the process of metastasis in some cancers, Snail and Twist are the two transcription factors, function as EXCEPT

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#Question id: 15362

#Unit 4. Cell Communication and Cell Signaling

Aflatoxin a fungal metabolite found in moldy grains, induces

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#Question id: 15361

#Unit 4. Cell Communication and Cell Signaling

The chemical benzo(a)pyrene, found in cigarette smoke as well as in coal tar, undergoes metabolic activation in the lungs to form a potent mutagen that mainly, causes conversion of guanine (G) to thymine (T) bases, a transversion mutation, When applied to cultured bronchial epithelial cells, activated benzo(a)pyrene induces many mutations, including inactivating mutations of the p53 gene, at codon number______

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#Question id: 15307

#Unit 4. Cell Communication and Cell Signaling

In attached table some Tumor‐Suppressor Genes are given with their inherited syndrome; select correctly matched genes with their causing syndrome

Gene	Inherited syndrome
i. TP53	Li-Fraumeni syndrome
ii. INK4a	Familial melanoma
iii. PTEN	Familial gastric cancer
iv. E-Cadherin	Cowden disease
v. VHL	von Hippel-Lindau syndrome

TLS Online TPP Program

#Question id: 15306

#Unit 4. Cell Communication and Cell Signaling

The transformation of a normal cell to a cancer cell is accompanied  by the loss of function of one or more tumor‐suppressor genes. High‐throughput sequencing studies have identified hundreds of genes that are implicated as tumor suppressors in humans. Some of the better characterized genes;

Gene	Primary tumor	Proposed function
i) APC	Colorectal	Binds β-catenin acting as transcription factor
ii) BRCA1	Breast	DNA repair
iii) MSH2, MLH1	Melanoma, pancreatic	p16: Cdk inhibitor ARF: stabilizes p53
iv) E-Cadherin	Breast, colon	Cell adhesion molecule
v) INK4a	Colorectal	Mismatch repair
vi) NF1	Neurofibromas	Activates GTPase of Ras

Choose incorrect matching regarding tumor‐suppressor genes/primary tumor/proposed functions;