#Question id: 5072
#Unit 5. Developmental Biology
Movement of epithelial cells as a unit to enclose deeper layers of the embryo. This type of cell movement during gastrulation occur in:
#Question id: 2941
#Unit 2. Cellular Organization
Centromeric Rec8 becomes cleaved during:
#Question id: 11967
#Unit 7. System Physiology – Animal
#Question id: 1582
#Unit 4. Cell Communication and Cell Signaling
The EBV antigen fragments will be presented by the virus-infected cells along with which of the following?
#Question id: 880
#Unit 1. Molecules and their Interaction Relevant to Biology
The classic work of Christian Anfinsen in the 1950s on the enzyme ribonuclease revealed the relation between the amino acid sequence of a protein and its conformation. Ribonuclease is a single polypeptide chain consisting of 124 amino acid residues cross-linked by four disulfide bonds. Anfinsen’s plan was to destroy the three-dimensional structure of the enzyme and to then determine what conditions were required to restore the structure.
The critical observation of Anfinsen that the denatured ribonuclease, freed of urea and b -mercaptoethanol by dialysis;
I. The sulfhydryl groups of the denatured enzyme became reduced by air, and the enzyme spontaneously refolded into a catalytically active form.
II. These experiments showed that the information needed to specify the catalytically active structure of ribonuclease is contained in its amino acid sequence.
III. The 105 wrong pairings have been picturesquely termed “scrambled” ribonuclease.
IV. He found that scrambled ribonuclease spontaneously converted into fully active, native ribonuclease when trace amounts of b -mercaptoethanol were added to an aqueous solution of the protein.
Choose incorrect options;