TLS Online TPP Program

#Question id: 2990


Mitotic CDK complexes are maintained in an inactive state through inhibitory phosphorylation of the CDK subunit. Two highly conserved tyrosine and threonine residues in mammalian CDKs are subject to regulated phosphorylation.

Gene

  Mutant phenotypes

A. Wee1

i. the cell does not divide but continues to grow

B. CAK kinase

ii. mitotic cyclins are inactivated

C. cdc25 phosphatase

iii. premature entry into mitosis

The following table enlists genes and phenotypes observed on mutation of these genes but not correctly matched. Which one of the following combinations is correctly matched ?

#I Life Science/ Life Sciences Group – I-V
  1. A - ii, B - i, C - iii

  2. A - i, B - iii, C - ii

  3. A - iii, B - ii, C - i

  4.  A - iii, B - ii, C – ii