TLS Online TPP Program

#Question id: 5132


Upon secretion of wnt, When Wnt attaches to the Frizzled receptor on a responding cell, the cell secretes Notum, a hydrolase that associates with glypican and then cleaves off Wnt’s attached lipids in a process of deacylation or delipidation. This process:

#SCPH01 Biochemistry
  1. reduces Wnt signaling because the lipids are essential for Wnt to bind to Frizzled

  2. Increases wnt signaling because lipids are not essential for wnt to bind to frizzled

  3. Firstly increases, later on reduces wnt signalling.

  4. Firstly reduces, later on increase wnt signaling