Following statements are regarding to the spindle position checkpoint pathway in budding yeast.

A. During interphase and early mitosis, Cdc14 is sequestered and inactivated in the nucleolus. Inactive Tem1-GDP associates with the spindle pole body (SPB) nearest to the bud as soon as the mitotic spindle forms.

B. If chromosome segregation occurs properly, extension of the spindle microtubules inserts the daughter SPB into the bud, causing Tem1 to be activated by an unknown mechanism.

C. Tem1-GDP activates a protein kinase cascade, which then promotes the release of active Cdc14 from the nucleolus and exit from mitosis.

D. If the spindle apparatus fails to place the daughter SPB in the bud, Kin4 (cyan), an inhibitor of Tem1, is recruited from the parent cell cortex to the parent-cell-located SPB and maintains Tem1 in the GTP-bound form, and mitotic exit does not occur.

Which of the following are correct?

#Question id: 818

#SCPH05 I Biotechnology

Which one of the following weak interactions have central features of protein structures, but makes only minor contributions to protein stability?

#Question id: 12921

#SCPH01 Biochemistry

#Question id: 11601

#I Life Science/ Life Sciences Group – I-V

Gibberellin is an important plant hormone that regulates several aspects of plant growth and development. Some statements are given below in relation to  signalling pathways:

a) The binding of gibberellin (GA) to its receptor leads to the degradation of the DELLA repressor by the 26S proteasome

b) Gibberellin binds to the GID1 receptor and induces a conformational change in the N-terminal domain of the receptor, allowing the receptor to interact with the TVHYNP and DELLA domains of the DELLA repressor

c) The formation of the GID1-repressor complex promotes the interaction between the repressor and the E3 ubiquitin ligase SCF^TIR1 complex, leading to the ubiquitination and degradation

d) The gibberellin receptor GIBBERELLIN INSENSITIVE DWARF 1 (GID1) also itself function as an F-box protein

Which one of the following is the incorrect statements about GA  signalling pathway;

#Question id: 94

#SCPH01 Biochemistry

A monosaccharide whose anomeric carbon atom has a glycosidic bond to an alcohol, amine or thiol is a ________.

#Question id: 15608

#SCPH05 I Biotechnology