During ubiquitin-mediated protein degradation in various events of cell cycle, ubiquitin-protein ligases ubiquitinylate substrate proteins, marking them for degradation by proteasomes. Cyclins are degraded through the action of two different ubiquitin-protein ligases, SCF and the anaphase-promoting complex or cyclosome. Following statements are regarding to SCF and APC/C.

A. SCF controls the G1–S phase transition by degrading G1/S phase cyclins and, CDK inhibitory proteins.

B. APC/C degrades S phase and mitotic cyclins, thereby promoting the exit from mitosis.

C. SCF and APC/C are multi-subunit ubiquitin-protein ligases that belong to the RING finger family of ubiquitin protein ligases.

D. SCF and APC/C belong to the different ubiquitin-protein ligase family, their regulation is same.

E. SCF recognizes its substrates only when they are phosphorylated.

F. SCF and APC/C both recognizes its substrates only when they are phosphorylated.

Which of the following is incorrect?

TLS Online TPP Program

#Question id: 15010

#SCPH01 Biochemistry

The phenomenon where half the "normal" level of functional protein is not enough to generate a normal phenotype is called haploinsufficiency. Which of the following situations demonstrates haploinsufficiency?

TLS Online TPP Program

#Question id: 15010

#SCPH12 I Genetics

The phenomenon where half the "normal" level of functional protein is not enough to generate a normal phenotype is called haploinsufficiency. Which of the following situations demonstrates haploinsufficiency?

TLS Online TPP Program

#Question id: 15011

#SCPH01 Biochemistry

Which of the following statements about a lethal allele is NOT correct?

TLS Online TPP Program

#Question id: 15011

#SCPH12 I Genetics

Which of the following statements about a lethal allele is NOT correct?

TLS Online TPP Program

#Question id: 15138

#SCPH01 Biochemistry

Match the items in group 1 with an appropriate description in group 2.

Group 1                                                                Group 2

(P) SWISS PROT                                 (1) derived protein structure database 

(Q) Local alignment                          (2) protein sequence database

(R) CATH                                             (3) GAP

(S) Global alignment                        (4) Smith–Waterman algorithm

TLS Online TPP Program

#Question id: 15138

#I Life Science/ Life Sciences Group – I-V

Match the items in group 1 with an appropriate description in group 2.

Group 1                                                                Group 2

(P) SWISS PROT                                 (1) derived protein structure database 

(Q) Local alignment                          (2) protein sequence database

(R) CATH                                             (3) GAP

(S) Global alignment                        (4) Smith–Waterman algorithm