TLS Online TPP Program

#Question id: 12221


Juvenile (type I) diabetes mellitus is often diagnosed because of polyuria (high urine flow) and polydipsia (frequent drinking) that occur because of which of the following?

#7. System Physiology – Animal
  1. Increased delivery of glucose to the collecting duct interferes with the action of antidiuretic hormone
  2. Increased glomerular filtration of glucose increases Na+ reabsorption via the sodium-glucose co-transporter
  3. When the filtered load of glucose exceeds the renal threshold, a rising glucose concentration in the proximal tubule decreases the osmotic driving force for water reabsorption
  4. High plasma glucose concentration decreases thirst