TLS Online TPP Program

#Question id: 18081


The interaction of selection and inbreeding in determining the incidence of autosomal recessive diseases. Consider a gene in which recessive mutations occur at a rate of 10-5. Assume a selective disadvantage S of 0.4 in homozygotes for the recessive allele. What is the frequency of the recessive allele (q). And calculate the incidence of the disease. Assume random mating.

#Unit 8. Inheritance Biology
  1. q =0.0001,  incidence of the disease in the population would be 8.104 X 10-6
  2. q =0.005,  incidence of the disease in the population would be 2.5 X 10-5
  3. q =0.025,  incidence of the disease in the population would be 6.4 X 10-3
  4. q =0.025,  incidence of the disease in the population would be 6.77 X 10-6