Previous Year Questions

QUESTION ID:2

Amongst the following, the elongated, fibrous protein is 

QUESTION ID:3

The mutation likely to cause the least perturbation in the tertiary structure of a protein is 

QUESTION ID:4

Match the techniques in column I with their primary applications in Column II: 

QUESTION ID:5

Amongst the following statements about biological membranes, the INCORRECT one is that they 

QUESTION ID:6

The introduction of a new fish species into a lake resulting in the extinction of several native fish species from the lake is an example of 

QUESTION ID:7

The taxonomic hierarchy in descending order of size is 

QUESTION ID:8

If the recessive disease phenylketonuria (PKU) occurs in a genetically constant population with a frequency of 1 in 10000, the frequency of the carrier genotype is 

QUESTION ID:9

Amplification of a DNA fragment by PCR yields only one faint band of the expected size on an agarose gel. For such a sample, the best way to increase the yield of the PCR product is to 

QUESTION ID:10

The cellular organelle which function(s) as a store for Ca²+ ions is 

QUESTION ID:11

If the N-terminal 21 amino acids were missing from a mitochondrial protein, its cellular location after synthesis would be 

QUESTION ID:12

Packaged biomaterials are dispatched to intracellular and extracellular locations from the 

QUESTION ID:13

The preferred ligand for SH2 domain is 

QUESTION ID:14

The binding of a hormone to its receptor activates adenylyl cyclase through a stimulatory G protein. If, due to a mutation, the G-protein binds but does NOT hydrolyze GTP, the consequence will be 

QUESTION ID:15

QUESTION ID:16

Bt toxin, produced by Bacillus thuringiensis, does NOT kill the bacteria itself because the toxin is 

QUESTION ID:17

The inactivation of an mRNA due to its binding to a complementary RNA molecule is called 

QUESTION ID:18

Given are the sequences of one strand of double-stranded DNA. The one with the highest melting point (Tm) is 

QUESTION ID:19

The standard pregnancy kit, used to detect Human Chorionic Gonadotrophin (HCG) in urine, is based on 

QUESTION ID:20

The preferred system for large-scale production of influenza virus for vaccination is 

QUESTION ID:21

QUESTION ID:22

The lac repressor is produced from a stretch of DNA called the 

QUESTION ID:23

The repeating units in chitin are 

QUESTION ID:24

The correct ascending order of melting points of oleic acid (O), linoleic acid (L), palmitic acid (P) and stearic acid (S) is 

QUESTION ID:25

A peptide Glu-His-Trp-Ser-Gly-Leu-Arg-Pro-Gly, having an isoelectric point of 7.8, is placed in an electric field at pH 3.0. It will migrate towards 

QUESTION ID:26

X-ray diffraction of wool shows repeated structural units spaced at 5.2 Å, which is changed to 7.0 Å on steaming. This is due to the conversion of secondary structure from 

QUESTION ID:27

At E_t = 20 nm and substrate concentration = 40 µM, the reaction velocity V_o of an enzyme is 9.6 µM s^-1. Assuming k_cat to be 600 s^-1, the K_M will be 

QUESTION ID:28

Which of the following statements is NOT true for an enzyme catalyzed reaction? 

QUESTION ID:29

Which of the following is NOT an allosteric regulatory enzyme in glycolysis? 

QUESTION ID:30

Match the enzymes of TCA cycle in Group I with that of their products listed in Group II. 

QUESTION ID:31

Addition of the uncoupler 2,4- Dinitrophenol to actively respiring mitochondria causes 

QUESTION ID:32

C₄ plants overcome photorespiration activity of Rubisco by fixing CO₂, firstly as 

QUESTION ID:33

Which of the following is a non-symbiotic nitrogen fixing bacteria? 

QUESTION ID:34

Vasopressin, an antidiuretic hormone, responsible for increased absorption of water by the kidney, is secreted from 

QUESTION ID:35

Match the vitamins in Group I with their deficiency disorders listed in Group II. 

QUESTION ID:36

QUESTION ID:37

Which part of the human brain controls body temperature? 

QUESTION ID:38

The action potential for initiating and maintaining the rhythmic contraction of heart is generated by 

QUESTION ID:39

The antigen binding sites in immunoglobulin IgG are present at 

QUESTION ID:40

Fertilization of human sperm and ovum takes place in the 

QUESTION ID:41

Match the pathogenic microorganisms in Group I with the diseases listed in Group II. 

QUESTION ID:42

An example of a eukaryotic chemoorganotroph microorganism lacking chlorophyll and having mycelial thallus is 

QUESTION ID:43

A Bacillus sp. divides every 30 min. If a culture is inoculated with 1000 cells, how many cells will be generated after 3 hrs? 

QUESTION ID:44

The selective media mannitol salt agar is used for the isolation of 

QUESTION ID:45

In liver cells, glucose is converted to glucose-6-P which can then be utilized towards glycolysis or glycogen synthesis. If K_M^Glycolysis and K_M^Glycogen correspond to the enzymes involved in the first steps of glycolysis and glycogen synthesis, the true statement amongst the following is: (DROP)

QUESTION ID:46

An enzyme requires both aspartate (pKa of side chain = 4.5) and histidine (pKa of side chain = 6.5) residues in the catalytic site to be protonated for activity. The expected enzyme activity (in %) at a pH of 5.5 would be closest to

QUESTION ID:47

By weight, 95% of an E. coli cell's components are water (~70%), protein (~15%), nucleic acids (DNA 1% + RNA6%) and polysaccharides (~3%). Given that there is only one chromosome and about 3000 different proteins in an E. coli cell lysate, the number of different molecules of DNA and RNA is expected to be 

QUESTION ID:48

QUESTION ID:49

The monomer which leads to a conducting polymer is 

QUESTION ID:50

The pH at the equivalence point when 50 mL of 0.1 M acetic acid is titrated against 0.1 M NaOH is closest to

QUESTION ID:51

The mass (in g) of glycine, NH₂CH₂COOH, required to make 250 mL of a 0.015 M solution is (Atomic weights in amu: H=1, C=12, N=14, O=6). (DROP)

QUESTION ID:52

The arrangement of ligands in ascending order of the crystal field splitting is 

QUESTION ID:53

QUESTION ID:54

QUESTION ID:55

In the reaction sequence below, X, Y, and Z, respectively, are 

QUESTION ID:56

On completion of the reaction 

the Br atom is attached to carbon atom

QUESTION ID:57

QUESTION ID:58

The major product, Z, obtained in the reaction

QUESTION ID:59

The compound that shows a line in the ¹H NMR spectrum at the lowest δ value is 

QUESTION ID:60

Water is injected into a balloon filled with ammonia gas. The balloon shrinks and it is hot to touch. According to the convention ∆U = q + w, for this process 

QUESTION ID:61

A process CANNOT occur spontaneously at constant T and P when 

QUESTION ID:62

If an atomic orbital has 2 radial nodes and 1 angular node, it is a 

QUESTION ID:63

QUESTION ID:64

A mixture initially containing 2 mol of CO and 2 mol of H₂ comes to equilibrium with methanol, CH₃OH, as the product of the reaction CO (g) + 2H₂ (g) → CH₃OH (g). At equilibrium the mixture will contain 

QUESTION ID:65

Given that the standard electrode potentials E° (Cu²⁺|Cu) = +0.340 V and E° (Cu⁺|Cu) = +0.522 V, the E° (Cu²⁺|Cu⁺) is 

QUESTION ID:66

The number of water molecules required to balance the chemical reaction when MnO₄^- is converted to MnO₂ in basic solution is

QUESTION ID:67

For a reaction a A+ b B → c C+ d D, the relation that holds is

QUESTION ID:68

Match the type of transition in the left column with the frequency of the electromagnetic radiation in the right column. 

QUESTION ID:69

QUESTION ID:70

QUESTION ID:71

A jellyfish appearing translucent in the sea disappears when immersed in an aquarium having liquid X. If the refractive index of the jellyfish is n, refractive index of X is 

QUESTION ID:72

The dimensions of shear strain are 

QUESTION ID:73

In S.I. units, electric flux, which is the dot product of electric field intensity and area vector, are 

QUESTION ID:74

QUESTION ID:75

If a human heart beats at an average frequency of 1.25 Hz, the number of beats per minute 

QUESTION ID:76

For a mammalian skeletal muscle, if the extracellular potassium ion concentration, [K⁺]_out = 4mM and, the intracellular potassium ion concentration, [K⁺]_in = 128mM , the potassium ion (K⁺) potential (in mV) is Assume: Faraday's constant = 9.65 x10⁴ * Cmol^-1 ; Gas constant = 8.31 J K^-1 mol^-1; mammalian temperature 37°C 

QUESTION ID:77

QUESTION ID:78

Aqueous environment in a spherical endosome a closed vesicle of 100 nm diameter, is at a pH 5.0, in order to denature and hydrolyze the material internalized by a cell. Assuming Avogadro's number to be 6x10²³ the number of free protons in an endosome is closest to

QUESTION ID:79

QUESTION ID:80

QUESTION ID:81

The maximum depth (in m) reachable by a research submarine, designed to withstand an external pressure of 100 atm, is 

Assume: Density of water = 1000kg / (m³) acceleration due to gravity= 10 m/s², and, atmospheric pressure at the water surface = 1 atm = 10⁵ Pa

QUESTION ID:82

QUESTION ID:83

If the four bases, A, T, G, and C, occur with equal likelihood in a five nucleotide DNA sequence, the approximate probability of finding the sequence CGAGT through random chance is 

QUESTION ID:84

A new life form has DNA with 5 nucleotides instead of 4, 5 naturally occurring amino acids instead of 20, and a codon size of 2 bases instead of 3. Assuming the central dogma of biology applies to the new life form, the degeneracy of its genetic code 

QUESTION ID:85

20 microbial colonies appear on an agar plate having sucrose and cellulose as the only carbon sources. Of the 20 colonies, microbes in 12 colonies can metabolize sucrose. If microbes in 4 colonies metabolize both sucrose and cellulose, the number of colonies with microbes which can metabolize cellulose is

QUESTION ID:86

A heavy chain of an immunoglobulin is a result of recombination of one DNA segment each from 200 different V segments, 12 D segments and 4 J segments from the corresponding DNA sequence. Further, a light chain results from recombination of one segment each from 200 different V segments with 5 different J segments. If a heavy chain and a light chain form an immunoglobulin, the maximum number of different immunoglobulins that can be synthesized is closest to

QUESTION ID:87

Weight of a colony of a newly discovered unicellular organism can be predicted by the empirical equation W (ing) = (x)ⁿ, where x = 1.01 and n = number of cells in the colony. If a dog weighs 10 kg, the correct statement amongst the following is 

QUESTION ID:88

Given that a hetero-trimeric protein is formed by 3 proteins with their center of masses at the coordinates (1, 1, 2), (3, 5, 7) and (-1, 7, -6) respectively, the coordinates of the centroid of the triangle formed by joining the three center of masses is 

QUESTION ID:89

Two linear and parallel RNA strands, defined by the equations 3x - 4y + 6 = 0 and 3x - 4y + 5 = 0 are hydrogen bonded together. The distance between the two strands is

QUESTION ID:90

(p, q+r), (q, r+p), and (r, p+q) are the coordinates of 3 co-planar atoms in a molecular structure. Area occupied by the three atoms is