Calcineurin phosphatase, dephosphorylates and activates the transcription factor, Nuclear Factor Associated with T cells (NFAT).

TLS Online TPP Program

#Id: 1445

#Unit 4. Cell Communication and Cell Signaling

Focal adhesion

Function- Shape, signaling, force transmission, cell movement

TLS Online TPP Program

#Id: 1446

#Unit 4. Cell Communication and Cell Signaling

Tight junctions seal off body cavities and restrict diffusion of membrane components.

TLS Online TPP Program

#Id: 1447

#Unit 4. Cell Communication and Cell Signaling

Tight junctions prevent the diffusion of: 

Macromolecules

Small water-soluble molecules

Ions

Membrane proteins 

Glycolipids

TLS Online TPP Program

#Id: 1448

#Unit 4. Cell Communication and Cell Signaling

Ca2+-dependent cadherin- mediated adhesion also plays an important role in tight-junction formation, stability, and function.

TLS Online TPP Program

#Id: 1449

#Unit 4. Cell Communication and Cell Signaling

Gap junctions permit the passage of molecules as large as 1.2 nm in diameter (molecules smaller than 1200 Da).

TLS Online TPP Program

#Id: 1450

#Unit 4. Cell Communication and Cell Signaling

Ions, low-MW precursors of cellular macromolecules, products of intermediary metabolism, & small intracellular signaling molecules can pass from cell to cell through gap junctions.