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TLS Online TPP Program

#Id: 10039

Activated IRAK1/2, binds TRAF6, an E3 ubiquitin ligase, to the signalsome, and promotes the formation of an extended 2-D lattice formed by TRAF6-TRAF6 interactions.

#Unit 4. Cell Communication and Cell Signaling #Delta Notch Signaling #Part B Pointers
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TLS Online TPP Program

#Id: 6280

#Unit 3. Fundamental Processes

Core enzyme binds indiscriminately to any DNA. Sigma factor reduces the affinity for sequence-independent binding and confers specificity for promoters.
TLS Online TPP Program

#Id: 6281

#Unit 3. Fundamental Processes

Holoenzyme binds to promoters much more tightly, with an association constant ,1000 times higher on average and a half-life that can be as long as several hours
TLS Online TPP Program

#Id: 6282

#Unit 3. Fundamental Processes

significantly higher dissociation rate at 25C than at 37C, and a much higher dissociation rate at 15C. Because high temperature promotes DNA melting
TLS Online TPP Program

#Id: 6283

#Unit 3. Fundamental Processes
TLS Online TPP Program

#Id: 6284

#Unit 3. Fundamental Processes

Mechanism: How Polymerase Find Promoter Sequences
TLS Online TPP Program

#Id: 6285

#Unit 3. Fundamental Processes