The force accompanying the movement of Delta into the signaling cell stretches the Notch protein on the responding cell and allowing access by ADAM 10, which cleaves the Notch extracellular domain

TLS Online TPP Program

#Id: 7237

#Unit 5. Developmental Biology

B cell is type of lymphocyte. B cell synthesized and maturation in Bone marrow.

TLS Online TPP Program

#Id: 7238

#Unit 5. Developmental Biology

Stages in hematopoiesis

TLS Online TPP Program

#Id: 7239

#Unit 5. Developmental Biology

B cell properties 

They are APCs

They can express MHC2

Have surface marker  CD19

Antibodies at surface of b cell – IgM, IgD

Part of Adaptive immunity 

B cell convert into plasma cell

TLS Online TPP Program

#Id: 7240

#Unit 5. Developmental Biology

Surface protein on B cell

CR2(CR21)

CD19

TAPA-1(CD81)

mIg 

Igα/ Igβ

(CD79a and CD79B)

TLR

CD40

B7 (CD80/86)

ICAM-1

MHC-1 and 2

CD 22

TLS Online TPP Program

#Id: 7241

#Unit 5. Developmental Biology

Formation of mature B-cell

TLS Online TPP Program

#Id: 7242

#Unit 5. Developmental Biology

Progress through their developmental program