Cleavage by the γ-secretase complex releases the Notch cytosolic segment, which translocates to the nucleus, interacts with a single DNA-binding transcription factor, CSL.

TLS Online TPP Program

#Id: 10427

#Unit 4. Cell Communication and Cell Signaling

miR-21 targets PTEN phosphatase

TLS Online TPP Program

#Id: 10428

#Unit 4. Cell Communication and Cell Signaling

DNA methylation occurs at cytosines of CpG islands, leads to repression of the promoters. DNA hypermethylation & DNA hypomethylation is also a hallmark of cancer.

TLS Online TPP Program

#Id: 10429

#Unit 4. Cell Communication and Cell Signaling

Acute myeloid leukemias

characterized by DNA hypomethylation, due to inactivating mutations in an enzyme that catalyzes the methylation of CpG dinucleotides.

TLS Online TPP Program

#Id: 10430

#Unit 4. Cell Communication and Cell Signaling

SWI/SNF normally plays a role in repressing the E2F genes, inhibiting progression through the cell cycle.

TLS Online TPP Program

#Id: 10431

#Unit 4. Cell Communication and Cell Signaling

SNF5 protein is a core member of SWI/SNF complex. In humans, inactivating somatic SNF5 mutations cause rhabdoid tumors.

TLS Online TPP Program

#Id: 10432

#Unit 4. Cell Communication and Cell Signaling

Carcinogens are mutagens, they act by altering one or more nucleotides in DNA.