The key CAMs in desmosomes are the desmosomal cadherins, desmoglein and desmocollin

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#Id: 10370

#Unit 4. Cell Communication and Cell Signaling

HLA-G

These are present on fetal cells at the maternal-fetal interface and are credited with inhibiting rejection by maternal CD8+ T cells by protecting the fetus from identification as foreign.

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#Unit 4. Cell Communication and Cell Signaling

A given MHC molecule can bind numerous different peptides, and some peptides can bind to several different MHC molecules. Because of this MHC molecule is often referred to as “promiscuous”.

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#Id: 10372

#Unit 4. Cell Communication and Cell Signaling

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#Unit 4. Cell Communication and Cell Signaling

MHC-Peptide Interaction

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#Id: 10374

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10375

#Unit 4. Cell Communication and Cell Signaling

One individual, however, expresses only a small number of these molecules—up to six different class I molecules and 12 or more different class II molecules.