Lineage commitment

TLS Online TPP Program

#Id: 1138

#Unit 2. Cellular Organization

Inhibitory Proteins in Cell Cycle-

Sic1 - Binds and inhibits S phase CDKs

CKIs p27, p57, and p21- Bind and inhibit CDKs

INK4 - Binds and inhibits G1 CDKs

Rb - Binds E2Fs

TLS Online TPP Program

#Id: 1139

#Unit 2. Cellular Organization

Ubiquitin-Protein Ligases-

SCF- Degradation of phosphorylated Sic1

TLS Online TPP Program

#Id: 1140

#Unit 2. Cellular Organization

Ubiquitin-Protein Ligases-

APC/CCdc20 - Degradation of securin, initiating anaphase, Induces degradation of B-type cyclins

TLS Online TPP Program

#Id: 1141

#Unit 2. Cellular Organization

Ubiquitin-Protein Ligases-

APC/CCdh1 - Degradation of B-type cyclins in G1 and geminin in metazoans to allow loading of replicative helicases on DNA replication origins.

TLS Online TPP Program

#Id: 8598

#Unit 2. Cellular Organization

Labile factors called cyclins drive the progression of cells through different stages of the cell cycle by binding to CDKs.

TLS Online TPP Program

#Id: 8599

#Unit 2. Cellular Organization

Cells commit to a new cell division at a specific point in G1 known as START or the restriction point.