TLS Online TPP Program

#Id: 9673

#Unit 4. Cell Communication and Cell Signaling

Ligand-induced receptor activation,

Concentration of PI 3-phosphates rises

PH domain of PKB binds to PI 3-phosphates

TLS Online TPP Program

#Id: 9674

#Unit 4. Cell Communication and Cell Signaling

Maximal activation of PKB depends on recruitment to the cytosolic surface of the plasma membrane of two other kinases -PDK1 and PDK2.

TLS Online TPP Program

#Id: 9675

#Unit 4. Cell Communication and Cell Signaling

PDK1 can phosphorylate PKB on a critical threonine residue in its activation loop

TLS Online TPP Program

#Id: 9676

#Unit 4. Cell Communication and Cell Signaling

Phosphorylation by the mTORC2 kinase complex, of a second serine on

PKB that is not in the activation loop is necessary for maximal PKB activity

TLS Online TPP Program

#Id: 9677

#Unit 4. Cell Communication and Cell Signaling

Activated PKB directly phosphorylates and inactivates a protein Bad

TLS Online TPP Program

#Id: 9678

#Unit 4. Cell Communication and Cell Signaling

Activated PKB also promotes survival of many cultured cells by phosphorylating the Forkhead transcription factor FOXO3a on multiple serine and threonine residues.