Nurturing Life Sciences
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#Unit 5. Developmental Biology
In prespore cells, PKA activation occurs by signalling cascade that is activated by SDF-3, which triggers the synthesis of GABA
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Secreted GABA then acts on prestalk cells to induce the cell-surface exposure of the serine protease domain of the ABC transporter TagC.
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GABA acts on prespore cells to induce secretion of AcbA.
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AcbA is cleaved by the TagC protease to produce the peptide SDF-2.