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TLS Online TPP Program

#Id: 10386

Presentation of nonpeptide antigens derived from pathogens involves the nonclassical class I–like CD1 molecule

#Unit 4. Cell Communication and Cell Signaling #Major histocompatibility complex #Part B Pointers
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TLS Online TPP Program

#Id: 9979

#Unit 4. Cell Communication and Cell Signaling

Active Wnt signaling leads to the secretion of Notum.
TLS Online TPP Program

#Id: 9980

#Unit 4. Cell Communication and Cell Signaling

Notum, a hydrolase that associates with glypican and then cleaves off Wnt’s attached lipids in a process of deacylation or delipidation.
TLS Online TPP Program

#Id: 9981

#Unit 4. Cell Communication and Cell Signaling

Delipidation process reduces Wnt signaling, creates a negative feedback mechanism for preventing excessive Wnt signaling.
TLS Online TPP Program

#Id: 9982

#Unit 4. Cell Communication and Cell Signaling

Frizzled receptor possesses a unique hydrophobic cleft adapted to interact with lipidated Wnts, a binding conformation mimicked in Notum’s structure as well.
TLS Online TPP Program

#Id: 9983

#Unit 4. Cell Communication and Cell Signaling
TLS Online TPP Program

#Id: 9984

#Unit 4. Cell Communication and Cell Signaling