Four stages of the evolutionary progression of cancer:

Initiation→Cancer progression → Evasion of cancer cell elimination  → Tumor growth and dispersal 

TLS Online TPP Program

#Id: 9706

#Unit 4. Cell Communication and Cell Signaling

Ligand binding to either of the two yeast pheromone GPCRs triggers the exchange of GTP for GDP on the Gα subunit and dissociation of Gα∙GTP from the Gβγ complex.

TLS Online TPP Program

#Id: 9621

#Unit 4. Cell Communication and Cell Signaling

Kinase domains typically contain two regions:

N and C lobes

TLS Online TPP Program

#Id: 1141

#Unit 2. Cellular Organization

Ubiquitin-Protein Ligases-

APC/CCdh1 - Degradation of B-type cyclins in G1 and geminin in metazoans to allow loading of replicative helicases on DNA replication origins.

TLS Online TPP Program

#Id: 2446

#Unit 3. Fundamental Processes

One consequence of the rotation of DNA is illustrated In the two-domain model for transcription, as RNA polymerase moves with respect to the double helix, it generates positive supercoils (more tightly wound DNA) ahead of it and leaves negative supercoils (partially unwound DNA) behind it. For each helical turn traversed by RNA polymerase, + 1 turn is generated ahead and -1 turn behind.

TLS Online TPP Program

#Id: 833

#Unit 4. Cell Communication and Cell Signaling

Hemibiotrophy where the pathogen initially keeps cells alive but at later stages of the infection, kills them.