Let-7 miRNAs repress the translation of Ras mRNA and also targets MYC

TLS Online TPP Program

#Id: 3677

#Unit 3. Fundamental Processes

Some prokaryotic ORFs lack a strong RBS but are nonetheless actively translated Using the phenomenon of translational coupling.

TLS Online TPP Program

#Id: 3678

#Unit 3. Fundamental Processes

The initiation of prokaryotic translation commences with the small subunit and is catalyzed by three translation initiation factors called IF1, IF2, and IF3.

TLS Online TPP Program

#Id: 3679

#Unit 3. Fundamental Processes

IF1 prevents tRNAs from binding to the portion of the small subunit that will become part of the A-site.

TLS Online TPP Program

#Id: 3680

#Unit 3. Fundamental Processes

IF2 is a GTPase (a protein that binds and hydrolyzes GTP) that interacts with three key components of the initiation machinery: the small subunit, IF1, and the charged initiator tRNA (fMet-tRNAi fMet).

TLS Online TPP Program

#Id: 3681

#Unit 3. Fundamental Processes

IF3 binds to the small subunit and blocks it from reassociating with a large subunit.

TLS Online TPP Program

#Id: 3682

#Unit 3. Fundamental Processes

IF3 is critical for a new cycle of translation.