A highly specific inhibitor imatinib (Gleevec), which

binds directly to the active site of the ABL kinase and holds it in an inactive conformation to inhibit its kinase activity, is lethal to CML cells

TLS Online TPP Program

#Id: 9936

#Unit 4. Cell Communication and Cell Signaling

Extracellular Bacteria

TLS Online TPP Program

#Id: 5906

#Unit 3. Fundamental Processes

Each DNA helicase moves along ssDNA in a defined direction. This property is referred to as the polarity of the DNA helicase. DNA helicases can have a polarity of either 5’->3’ or 3’->5’.

TLS Online TPP Program

#Id: 9676

#Unit 4. Cell Communication and Cell Signaling

Phosphorylation by the mTORC2 kinase complex, of a second serine on

PKB that is not in the activation loop is necessary for maximal PKB activity

TLS Online TPP Program

#Id: 7116

#Unit 6. System Physiology – Plant

ABA (C15) biosynthesis takes place in chloroplasts and cytosol from C40 precursor

ABA closes stomata in response to water stress

ABA promotes root growth and inhibits shoot growth at low water potentials

TLS Online TPP Program

#Id: 3991

#Unit 7. System Physiology – Animal

Phase 2 (plateau), calcium channels open and fast potassium channels close.