Children with hereditary (familial) retinoblastoma inherit one defective copy of the RB gene 

(sometimes seen as a small deletion on one of the two copies of chromosome 13)

TLS Online TPP Program

#Id: 677

#Unit 3. Fundamental Processes

Telomerase protein component with catalytic activity is encoded by EST2 in yeast, hTERT in humans

TLS Online TPP Program

#Id: 678

#Unit 3. Fundamental Processes

The RNA component is typically short 159 bases long in Tetrahymena, and 451 bases long in humans, though 1.3 kb in yeast

TLS Online TPP Program

#Id: 679

#Unit 3. Fundamental Processes

EST proteins regulates number of repeats in RNA component for telomere lengths.

TLS Online TPP Program

#Id: 680

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 681

#Unit 3. Fundamental Processes

Cdc13 is a positive activator of telomerase

TLS Online TPP Program

#Id: 682

#Unit 3. Fundamental Processes

Cdc13 binds to the single-stranded telomere repeat DNA and is involved in telomerase recruitment.