MDM2 levels in the cytoplasm are controlled by

ATR and p14ARF (p19ARF in the mouse), sequesters it in the nucleolus, where it cannot access p53.

TLS Online TPP Program

#Id: 10002

#Unit 4. Cell Communication and Cell Signaling

Desert hedgehog protein is found in the Sertoli cells of the testes

TLS Online TPP Program

#Id: 10003

#Unit 4. Cell Communication and Cell Signaling

Mice homozygous for a null allele of dhh exhibit defective spermatogenesis

TLS Online TPP Program

#Id: 10004

#Unit 4. Cell Communication and Cell Signaling

Indian hedgehog is expressed in the gut and cartilage and is important in postnatal bone growth

TLS Online TPP Program

#Id: 10005

#Unit 4. Cell Communication and Cell Signaling

Sonic hedgehog is responsible for assuring that motor neurons come only from the ventral portion of the neural tube & essential for normal patterning of the limbs

TLS Online TPP Program

#Id: 10006

#Unit 4. Cell Communication and Cell Signaling

Hedgehog protein with autoproteolytic activity that cleaves off the C-terminus to reveal a signal sequence that marks the protein for secretion.

TLS Online TPP Program

#Id: 10007

#Unit 4. Cell Communication and Cell Signaling