Ubiquitin-Protein Ligases-

APC/CCdh1 - Degradation of B-type cyclins in G1 and geminin in metazoans to allow loading of replicative helicases on DNA replication origins.

TLS Online TPP Program

#Id: 6107

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 6108

#Unit 3. Fundamental Processes

In ames test reversal mutants are formed by same mutagen which caused forward mutation.

A more potent mutagen translates

into a greater number of revertant colonies

TLS Online TPP Program

#Id: 6109

#Unit 3. Fundamental Processes

Some chemicals that cause cancers are not mutagenic to begin with, but rather are converted into mutagens by the liver, which metabolizes foreign substances. 

TLS Online TPP Program

#Id: 6110

#Unit 3. Fundamental Processes

There are 3 cellular ways to treat mutations on DNA

Repair- Most common

Reversal- Most expensive and rare

Bypass – Last resort and carry mutation without correction

TLS Online TPP Program

#Id: 6111

#Unit 3. Fundamental Processes

Genes whose products are involved in controlling the fidelity of DNA synthesis during either replication or repair may be identified by mutations that have a mutator phenotype called as mut system of repair or MMR

TLS Online TPP Program

#Id: 6112

#Unit 3. Fundamental Processes

Mismatch Repair removes errors that escape Proofreading