The innermost zone of the cortex, zona reticularis, and the middle zone, zona fasciculata, synthesize and secrete glucocorticoids and adrenal androgens. 

TLS Online TPP Program

#Id: 3865

#Unit 5. Developmental Biology

A second glycoprotein secreted during starvation is CMF (conditioned medium factor)

TLS Online TPP Program

#Id: 3866

#Unit 5. Developmental Biology

Histidine phosphatase activity of DhkA causes inactivation of RegA, the accumulation of cAMP and PKA activation, causes spore maturation.

TLS Online TPP Program

#Id: 3867

#Unit 5. Developmental Biology

CMF stimulates gene expression in parallel with PSF, and both signals potentiate cAMP signaling by inducing genes involved in cAMP synthesis and detection

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#Id: 3868

#Unit 5. Developmental Biology

In prespore cells, PKA activation occurs by signalling cascade that is activated by SDF-3, which triggers the synthesis of GABA

TLS Online TPP Program

#Id: 3869

#Unit 5. Developmental Biology

Newly activated genes are:

Adenylate cyclase A (ACA)
PKA
cAMP receptors (cARs)
Extracellular cAMP phosphodiesterase PdsA
An intracellular cAMP phosphodiesterase RegA

TLS Online TPP Program

#Id: 3870

#Unit 5. Developmental Biology

Secreted GABA then acts on prestalk cells to induce the cell-surface exposure of the serine protease domain of the ABC transporter TagC.