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TLS Online TPP Program

#Id: 1263

The innermost zone of the cortex, zona reticularis, and the middle zone, zona fasciculata, synthesize and secrete glucocorticoids and adrenal androgens. 


#Unit 7. System Physiology – Animal #Adrenocortical Hormones #Part B Pointers
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TLS Online TPP Program

#Id: 9092

#Unit 4. Cell Communication and Cell Signaling

Pertussis toxin, produced by Bordetella pertussis, catalyzes ADP-ribosylation of the  subunit of Gαi, preventing GDP-GTP exchange and blocking inhibition of adenylyl cyclase.
TLS Online TPP Program

#Id: 9093

#Unit 4. Cell Communication and Cell Signaling

Ligand binding to GPCRs that activate Gαq, leading to activation of phospholipase C
TLS Online TPP Program

#Id: 9094

#Unit 4. Cell Communication and Cell Signaling

Phospholipase C cleaves a phospholipid known as PI(4,5) P2, generating two second messengers: 
diffusible IP3 and membrane-bound DAG
TLS Online TPP Program

#Id: 9095

#Unit 4. Cell Communication and Cell Signaling
TLS Online TPP Program

#Id: 9096

#Unit 4. Cell Communication and Cell Signaling

IP3 triggers the opening of IP3-gated Ca2+ channels in the ER and elevation of cytosolic free Ca2+.
TLS Online TPP Program

#Id: 9097

#Unit 4. Cell Communication and Cell Signaling

In response to elevated cytosolic Ca2+ 
PKC is recruited to the plasma membrane, where it is activated by DAG