Phosphorylation of the activation loop leads to a conformational change in the JAK kinase that enhances the affinity of the enzyme for ATP & increasing kinase activity.

TLS Online TPP Program

#Id: 9211

#Unit 11. Evolution and Behavior

THE MAGNITUDE OF GENETIC DRIFT

n  = population size

pq=allelic frequency

sp2=variance in allelic frequency among the populations

TLS Online TPP Program

#Id: 9212

#Unit 11. Evolution and Behavior

Loss of their original diversity per generation

=1/2n

Gain of their original diversity per generation

=1/2n 

Gain or Loss of their original diversity per generation

=1/4n

TLS Online TPP Program

#Id: 9213

#Unit 11. Evolution and Behavior

Probability of being heterozygote in given population

H = 1 - 1/2N

TLS Online TPP Program

#Id: 9214

#Unit 11. Evolution and Behavior

Effective population size(Ne)

Effective number of breeding adults in a population.

TLS Online TPP Program

#Id: 9215

#Unit 11. Evolution and Behavior

Some factor determine Ne

1.Sex ratio.

2.Variation between individual in reproduction success.

3.Fluctuation in population size.

4.The age structure of the population.

5.Mating is random.

TLS Online TPP Program

#Id: 9216

#Unit 11. Evolution and Behavior

Ne = Male + Female  (when both are equal)

Ne = 4 × n(male) × n(female)/n(male)+n(female) 

(When both unequal Ne is smaller than then sum of both)