STAT homodimer has two phosphotyrosine-SH2 domain interactions

TLS Online TPP Program

#Id: 1616

#Unit 4. Cell Communication and Cell Signaling

Humans CLRs that function as PRRs, most of which recognize one or more specific sugar moieties such as mannose (e.g., the mannose receptor and DC-SIGN), fucose (e.g., Dectin-2 and DC-SIGN), and glucans (e.g., Dectin-1).

TLS Online TPP Program

#Id: 1617

#Unit 4. Cell Communication and Cell Signaling

Humans CLRs that function as PRRs, most of which recognize one or more specific sugar moieties such as mannose (e.g., the mannose receptor and DC-SIGN), fucose (e.g., Dectin-2 and DC-SIGN), and glucans (e.g., Dectin-1).

TLS Online TPP Program

#Id: 1618

#Unit 4. Cell Communication and Cell Signaling

Chronic inflammation causes by IL-6, TNFα, IL-1β, IL-18.

TLS Online TPP Program

#Id: 1619

#Unit 4. Cell Communication and Cell Signaling

IL-10 and TGF-β regulate inflammation.

TLS Online TPP Program

#Id: 1620

#Unit 4. Cell Communication and Cell Signaling

TLR4 is unique in binding both MyD88 (when it is in the plasma membrane, signaling its endocytosis) and TRIF (when it is in endosomes, after internalization).

TLS Online TPP Program

#Id: 1621

#Unit 4. Cell Communication and Cell Signaling

COX2, whose synthesis is induced by PRR activation in monocytes, macrophages, neutrophils, and mast cells, is key to converting the lipid intermediate arachidonic acid to prostaglandins, potent proinflammatory mediators.