Characterization of the disease-causing deletion showed that the absence of two miRNAs, miR-15-a and miR-16-1, causes chronic lymphocytic leukemia (CLL)

TLS Online TPP Program

#Id: 1434

#Unit 4. Cell Communication and Cell Signaling

Three major classes of animal-cell junctions: 

1. Anchoring junctions

2. Tight junctions

3. Gap junctions

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#Unit 4. Cell Communication and Cell Signaling

Four types of anchoring junctions are present in cells:

1. Adherens junctions

2. Desmosomes

3. Hemidesmosomes

4. Focal adhesions

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#Id: 1436

#Unit 4. Cell Communication and Cell Signaling

Adherens junctions 

Adhesion type- Cell-cell

Principal CAMs- Cadherins

Cytoskeletal attachment- Actin filaments

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#Id: 1437

#Unit 4. Cell Communication and Cell Signaling

Adherens junctions  functions as a tension cable that can internally brace the cell and thereby control its shape.

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#Id: 1438

#Unit 4. Cell Communication and Cell Signaling

Desmosomes

Adhesion type- Cell-cell

Cytoskeletal attachment- Intermediate filaments

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#Id: 1439

#Unit 4. Cell Communication and Cell Signaling

The key CAMs in desmosomes are the desmosomal cadherins, desmoglein and desmocollin.