Characterization of the disease-causing deletion showed that the absence of two miRNAs, miR-15-a and miR-16-1, causes chronic lymphocytic leukemia (CLL)

TLS Online TPP Program

#Id: 7788

#Unit 2. Cellular Organization

The mutations responsible for this altered cellular localization occur within a specific seven-residue sequence rich in basic amino acids near the C-terminus of the protein: Pro-Lys-Lys-Lys-Arg-Lys-Val.

TLS Online TPP Program

#Id: 7789

#Unit 2. Cellular Organization

Nuclear transport receptor

A general class of proteins that facilitate protein transport into or out of the nucleus by binding to a nuclear import sequence or a nuclear export sequence

TLS Online TPP Program

#Id: 7790

#Unit 2. Cellular Organization

Nuclear transport receptor

have affinity for FG-repeats on nucleoporins.

TLS Online TPP Program

#Id: 7791

#Unit 2. Cellular Organization

The mechanism for the import of cytoplasmic cargo proteins mediated by a nuclear transport receptor known as importin.

TLS Online TPP Program

#Id: 7792

#Unit 2. Cellular Organization

Ran is a small monomeric G protein

That exists in either a GTP-bound or a GDP-bound conformation & provides the energy to drive unidirectional transport of macromolecules through the nuclear pore.

TLS Online TPP Program

#Id: 7793

#Unit 2. Cellular Organization

Nuclear-export signal (NES)

ribonuclear protein complexes that shuttle between the nucleus and the cytoplasm. Such shuttling proteins contain NES.