C5b component is extremely labile, is not covalently bound to the membrane like C3b and C4b, and is rapidly inactivated unless it is stabilized by the binding of C6.

TLS Online TPP Program

#Id: 8895

#Unit 2. Cellular Organization

Monotelic attachment 

only one kinetochore can attach to microtubules

TLS Online TPP Program

#Id: 8897

#Unit 2. Cellular Organization

Sensing mechanism used by cells to detect incorrect chromosome attachments is based on tension.

TLS Online TPP Program

#Id: 8898

#Unit 2. Cellular Organization

If Amphitelic attachment occur  Microtubules pull kinetochores; cohesins resist this pulling force. The resulting tension leads to the outer kinetochore component Ndc80 being pulled away from the protein kinase Aurora B

TLS Online TPP Program

#Id: 8900

#Unit 2. Cellular Organization

The Aurora protein kinase family members Aurora A and Aurora B and their associated regulatory factors sense kinetochores that are not under tension and sever these microtubule attachments

TLS Online TPP Program

#Id: 8901

#Unit 2. Cellular Organization

Condensin association with chromosomes is facilitated by mitotic CDKs and Aurora B, which phosphorylate histone H2A, allowing condensins to bind chromatin.

TLS Online TPP Program

#Id: 8902

#Unit 2. Cellular Organization

Condensins package chromosomes by creating loops by forming intrachromosomal linkages and causes reduction in chromosome length, up to 10,000-fold in vertebrates.