Combination of Pax6, Sox2, and L-Maf in the ectoderm is needed for the production of the lens and the activation of lens-specific genes i.e. δ-crystallin.

TLS Online TPP Program

#Id: 8157

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8158

#Unit 2. Cellular Organization

Soluble ER-resident proteins contain C-terminal KDEL sorting signal that allows them to be retrieved. 

TLS Online TPP Program

#Id: 8159

#Unit 2. Cellular Organization

KDEL receptor, located mainly in the cis-Golgi network and in both COPII and COPI vesicles, binds proteins bearing the KDEL sorting signal and returns them to the ER

TLS Online TPP Program

#Id: 8160

#Unit 2. Cellular Organization

The KDEL receptor and other membrane proteins that

are transported Golgi to ER contain 

Lys-Lys-X-X sequence at C-terminal

TLS Online TPP Program

#Id: 8161

#Unit 2. Cellular Organization

KKXX sorting signal,

binds to a complex of the COPI α and β subunits

TLS Online TPP Program

#Id: 8162

#Unit 2. Cellular Organization

For selective export of certain membrane proteins from the ER contain a di-acidic sorting signal (Asp-X-Glu, or DXE), which binds to the Sec24 subunit of the COPII