Properties of epithelial-mesenchymal interactions:

Regional specificity of induction

Genetic specificity of induction

TLS Online TPP Program

#Id: 1725

#Unit 4. Cell Communication and Cell Signaling

Soluble CD23 binds to CD21 on the surface of IgE synthesizing B cells, IgE synthesis is increased.

TLS Online TPP Program

#Id: 1726

#Unit 4. Cell Communication and Cell Signaling

When membrane-bound CD23 binds to soluble IgE, further IgE synthesis is suppressed.

TLS Online TPP Program

#Id: 1727

#Unit 4. Cell Communication and Cell Signaling

FcεRIIB, bear immuno-receptor tyrosine inhibitory motifs Cross-linking of these receptors leads to inhibition, rather than to activation of cellular responses.

TLS Online TPP Program

#Id: 1728

#Unit 4. Cell Communication and Cell Signaling

If an allergen binds both IgG and IgE molecules, it will trigger signals through both Fc receptors. The inhibitory signal dominates.

TLS Online TPP Program

#Id: 1729

#Unit 4. Cell Communication and Cell Signaling

FcεRI pathways are phosphorylations, multiple phosphatases, such as SHPs, SHIPs, and PTEN, play an important role in dampening receptor signaling.

TLS Online TPP Program

#Id: 1730

#Unit 4. Cell Communication and Cell Signaling

Lyn, can play a negative as well as a positive role in FcεRI signaling by phosphorylating and activating the inhibitory FcεRIIB.