Epithelial-Mesenchymal Transition

An orderly series of events whereby epithelial cells are transformed into mesenchymal cells.

TLS Online TPP Program

#Id: 175

#Unit 5. Developmental Biology

In instructive interaction, 

a signal from the inducing cell is necessary for initiating new gene expression in the responding cell.

TLS Online TPP Program

#Id: 176

#Unit 5. Developmental Biology

Instructive interaction

It occur where the responding cell has a choice of fates and will follow one developmental pathway following induction and an alternative pathway in absence of the inductive signal. 

TLS Online TPP Program

#Id: 177

#Unit 5. Developmental Biology

In Permissive interaction

The responding tissue has already been specified and needs only an environment that allows the expression of these traits. 

TLS Online TPP Program

#Id: 178

#Unit 5. Developmental Biology

Epithelial-mesenchymal interactions

the interactions of sheets of epithelial cells with adjacent mesenchymal cells.

TLS Online TPP Program

#Id: 179

#Unit 5. Developmental Biology

Properties of epithelial-mesenchymal interactions:

Regional specificity of induction

Genetic specificity of induction

TLS Online TPP Program

#Id: 180

#Unit 5. Developmental Biology

Regional specificity of induction:

mesenchyme plays an instructive role, calling into play different sets of genes in the responding epithelial cells.