X-Linked Recessive Trait

a. Usually more males than females are affected.

b. Affected sons are usually born to unaffected mothers; thus, the trait skips generations.

c. Approximately half of a carrier (heterozygous) mother’s sons are affected.

d. Never passed from father to son.

e. All daughters of affected fathers are carriers.

TLS Online TPP Program

#Id: 1347

#Unit 4. Cell Communication and Cell Signaling

SOS – Ras GEF

NF1 - Ras GAP

TLS Online TPP Program

#Id: 1348

#Unit 4. Cell Communication and Cell Signaling

RasD or RasONC  Replacement of the normal glycine 12 with any other amino acid (except proline) “locks” Ras in the active GTP-bound state.

TLS Online TPP Program

#Id: 1349

#Unit 4. Cell Communication and Cell Signaling

RAF (also known as MAPKKK),  A ser/thr protein kinase

TLS Online TPP Program

#Id: 1350

#Unit 4. Cell Communication and Cell Signaling

KSR (Kinase suppressor of Ras) is a pseudogene homolog of RAF Involve in the activation of RAF

TLS Online TPP Program

#Id: 1351

#Unit 4. Cell Communication and Cell Signaling

CNK serves as a molecular scaffold platform for KSR-mediated RAF activation

 

TLS Online TPP Program

#Id: 1352

#Unit 4. Cell Communication and Cell Signaling

GRB2 SH3 domains bind to proline-rich sequences in Sos