COMPONENTS OF PHENOTYPIC VARIANCE

1. Genetic variance (Vg)

2. Environmental variance (Ve)

3. Genetic–environmental interaction variance (VGE)

TLS Online TPP Program

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#Unit 2. Cellular Organization

Attenuation is primarily based on riboswitch (Leader sequence) that function in co-translationally in trp operon

TLS Online TPP Program

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#Unit 2. Cellular Organization

Attenuator riboswitch (Leader sequence) is made up of almost 140 nt which further can be divided into four Intra -complementary regions 

TLS Online TPP Program

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#Unit 2. Cellular Organization

Attenuator riboswitch (Leader sequence) contains two major check-points in region 1

UGG codons on position 10, 11

A stop codon UGA between Region 1 and 2

TLS Online TPP Program

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#Unit 2. Cellular Organization

Attenuator riboswitch (Leader sequence) region 1 is translated atleast till codon 10 and 11 in case of Low trp concentration

TLS Online TPP Program

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#Unit 2. Cellular Organization

Region 1 Leader peptide is of 14 Amino acids Met------Ser 

TLS Online TPP Program

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#Unit 2. Cellular Organization

At high or low trp concentration, RNA Polymerase synthesizes full mRNA till region 4