In E. coli, rRNA synthesis from the seven rRNA operons responds to cellular growth rate and to changes in the availability of crucial nutrients, particularly amino acids. The regulation coordinated with amino acid concentrations is known as the stringent response.

TLS Online TPP Program

#Id: 415

#Unit 2. Cellular Organization

SQEL/Y motif of H2AX is phosphorylated by ATM/ATR kinases, activated by DNA damage, is involved in DNA repair

TLS Online TPP Program

#Id: 416

#Unit 2. Cellular Organization

H2AX phosphorylated at the SQEL/Y motif is sometimes referred to as “gamma-H2AX,”

TLS Online TPP Program

#Id: 417

#Unit 2. Cellular Organization

Gamma-H2AX frequently functions in DSBR

TLS Online TPP Program

#Id: 418

#Unit 2. Cellular Organization

H2AZ variant has 60% sequence identity with canonical H2A and involved in gene activation, heterochromatin–euchromatin boundary formation, cell-cycle progression.

TLS Online TPP Program

#Id: 419

#Unit 2. Cellular Organization

Mammalian macroH2A is enriched in the inactive X chromosome in females, which is assembled into a silent, heterochromatic state

TLS Online TPP Program

#Id: 420

#Unit 2. Cellular Organization

Mammalian H2ABbd variant is excluded from the inactive X and forms a less stable nucleosome than canonical H2A