Promoters with sequences closer to the consensus are generally “stronger” than those that match less well

TLS Online TPP Program

#Id: 8656

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8846

#Unit 2. Cellular Organization

In budding yeast CKI p27 = Sic1 in metazoans

TLS Online TPP Program

#Id: 8847

#Unit 2. Cellular Organization

When CDK activity is low= helicases are loaded in G1

When CDK activity is high= helicases are activated in

S, G2 & M

TLS Online TPP Program

#Id: 8848

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8849

#Unit 2. Cellular Organization

Phosphorylation of MCM helicase activators by G1/S phase CDKs and S phase CDKs, prevents reloading of MCM helicases (ensuring that replication from each origin occurs only once during each cell cycle)

TLS Online TPP Program

#Id: 8850

#Unit 2. Cellular Organization

Geminin 

a small protein,, that contributes to the inhibition of re-initiation at origins until cells complete a full cell cycle.