More than 90% of the genes expressed in mammals are alternatively spliced

TLS Online TPP Program

#Id: 10487

#Unit 4. Cell Communication and Cell Signaling

Neoantigens are self-antigens generated by tumor cells because of genomic mutations, also derive from unique proteins or peptides produced by dysregulated RNA splicing and disordered post-translational protein modification

TLS Online TPP Program

#Id: 10488

#Unit 4. Cell Communication and Cell Signaling

Most tumor cells,express MHC class I molecules on their surface, cytotoxic T cells can directly recognize tumor cells expressing neo-antigens.

TLS Online TPP Program

#Id: 10489

#Unit 4. Cell Communication and Cell Signaling

Cytotoxic T cells release granules containing the proteins perforin and granzyme-B

TLS Online TPP Program

#Id: 10490

#Unit 4. Cell Communication and Cell Signaling

perforins punch holes in the endocytic vesicle membrane, allowing granzymes to enter the cytoplasm

TLS Online TPP Program

#Id: 10491

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10492

#Unit 4. Cell Communication and Cell Signaling

Granzymes are serine proteases and cleave and activate

apoptotic molecules within the target cells, causing programmed cell death.