Termination depends on the RNA product and is not determined simply by scrutiny of the DNA sequence during transcription.

TLS Online TPP Program

#Id: 3272

#Unit 3. Fundamental Processes

Mismatch Repair Correction of the rare mismatches left after replication in E. coli improves the overall fidelity of replication by an additional factor of 10^2 to 10^3.

TLS Online TPP Program

#Id: 3273

#Unit 3. Fundamental Processes

The mismatch repair system of E. coli includes at least 12 protein components (Table) that function either in strand discrimination or in the repair process itself.

TLS Online TPP Program

#Id: 3277

#Unit 3. Fundamental Processes

Methylation of DNA strands can serve to distinguish parent (template) strands from newly synthesized strands in E. coli DNA

TLS Online TPP Program

#Id: 3279

#Unit 3. Fundamental Processes

 In Escherichia coli, mismatches are detected by a dimer of the mismatch repair protein MutS.

TLS Online TPP Program

#Id: 3280

#Unit 3. Fundamental Processes

MutS embraces the mismatch-containing DNA, inducing a pronounced kink in the DNA and a conformational change in MutS itself.

TLS Online TPP Program

#Id: 3281

#Unit 3. Fundamental Processes

MutS has an ATPase activity that is required for mismatch repair, in Escherichia coli, mismatches are detected by a dimer of the mismatch repair protein MutS.