Initiation relies solely upon the interaction between RNA polymerase and duplex DNA, however, the termination event also involves recognition of signals in the transcript by RNA polymerase.

TLS Online TPP Program

#Id: 1479

#Unit 4. Cell Communication and Cell Signaling

Characterization of the disease-causing deletion showed that the absence of two miRNAs, miR-15-a and miR-16-1, causes chronic lymphocytic leukemia (CLL)

TLS Online TPP Program

#Id: 1480

#Unit 4. Cell Communication and Cell Signaling

The miRNAs miR-15-a and miR-16-1 act like tumor-suppressors; they normally inhibit cell proliferation, and their absence leads to cell growth.

TLS Online TPP Program

#Id: 1481

#Unit 4. Cell Communication and Cell Signaling

Let-7 miRNAs down-regulate the translation of Ras. Thus in the absence of the miRNAs, Ras is constitutively overproduced, contributing to tumorigenesis.

TLS Online TPP Program

#Id: 1482

#Unit 4. Cell Communication and Cell Signaling

Neurofibromatosis, a benign tumor of the sheath cells that surround nerves, is caused by loss of both alleles of NF1, which encodes a RAS GAP-type protein.

TLS Online TPP Program

#Id: 1483

#Unit 4. Cell Communication and Cell Signaling

MYC is translocated close to an antibody gene, leading to overproduction of MYC IN Burkitt’s Lymphoma due to translocation from Chromosome 8 to 14.

TLS Online TPP Program

#Id: 1484

#Unit 4. Cell Communication and Cell Signaling

Monomers and dimers of p53, exists in the cytoplasm.