Agarose gels are formed  by suspending dry agarose in aqueous buffer, then boiling the mixture until a clear solution forms. 

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Intrinsic apoptosis pathway

Caspase-8 cleaves the BH3-interacting-domain death agonist (Bid), resulting tBid fragment

TLS Online TPP Program

#Id: 10557

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10558

#Unit 4. Cell Communication and Cell Signaling

tBid fragment binds to Bcl-2 on the outer mitochondrial membrane, leading to the dissociation of Bak and Bax and release of cytochrome c into the cytosol

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

In cells lacking functional caspase-8 or FADD, TNFα

triggers an alternative pathway, necroptosis.

TLS Online TPP Program

#Id: 10560

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10561

#Unit 4. Cell Communication and Cell Signaling

Necroptosis pathway triggered by activation of RIPK1 kinase.