There are two major advantages to running gradient gels. 

First, a much greater range of protein Mr values can be separated than on a fixed- percentage gel.

TLS Online TPP Program

#Id: 1438

#Unit 4. Cell Communication and Cell Signaling

Desmosomes

Adhesion type- Cell-cell

Cytoskeletal attachment- Intermediate filaments

TLS Online TPP Program

#Id: 1439

#Unit 4. Cell Communication and Cell Signaling

The key CAMs in desmosomes are the desmosomal cadherins, desmoglein and desmocollin.

TLS Online TPP Program

#Id: 1440

#Unit 4. Cell Communication and Cell Signaling

Desmosomes

Function- Strength, durability, signaling

TLS Online TPP Program

#Id: 1441

#Unit 4. Cell Communication and Cell Signaling

Hemidesmosomes

Adhesion type- Cell-matrix

Cytoskeletal attachment- Intermediate filaments

TLS Online TPP Program

#Id: 1442

#Unit 4. Cell Communication and Cell Signaling

The principal ECM adhesion receptor in epithelial hemidesmosomes is integrin α6β4.

TLS Online TPP Program

#Id: 1443

#Unit 4. Cell Communication and Cell Signaling

Hemidesmosomes

Function- Shape, rigidity, signaling