The partially hybridized primers may become extended by the DNA polymerase and are amplified; sometimes this may monopolize the PCR .

TLS Online TPP Program

#Id: 681

#Unit 3. Fundamental Processes

Cdc13 is a positive activator of telomerase

TLS Online TPP Program

#Id: 682

#Unit 3. Fundamental Processes

Cdc13 binds to the single-stranded telomere repeat DNA and is involved in telomerase recruitment.

TLS Online TPP Program

#Id: 683

#Unit 3. Fundamental Processes

POT1 binding to single-stranded telomere DNA inhibits telomere activity.

TLS Online TPP Program

#Id: 684

#Unit 3. Fundamental Processes

Structure of growing Telomere is potential target for DSBR

TLS Online TPP Program

#Id: 685

#Unit 3. Fundamental Processes

Attempts to repair telomeres in the DSBR manner as double-stranded DNA breaks would lead to chromosome fusion events, which eventually result in random chromosome breaks.

TLS Online TPP Program

#Id: 686

#Unit 3. Fundamental Processes

 Shelterin proteins bound at the telomere distinguish telomeres from other DNA ends in the cell prevents telomeres from normal DSBR